fedratinib will increase the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Alter dose of medication that are CYP3A4 substrates as important.

B: Might be acceptable. Either animal reports exhibit no threat but human research not accessible or animal scientific studies confirmed insignificant challenges and human research accomplished and showed no hazard.

In vitro measurements point out that 60% of modafinil is sure to plasma proteins at medical concentrations with the drug. This proportion variations hardly any if the focus of modafinil is different.[146]

levoketoconazole will improve the level or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

Suicidal thoughts or actions is usually due to matters besides medicines. If you have suicidal feelings or steps, your healthcare service provider might check for other will cause. Listen to any adjustments Particularly unexpected adjustments in temper, behaviors, thoughts, or emotions and keep all abide by-up visits with your Health care company as scheduled. Simply call your Health care company in between visits as desired, especially if you happen to be concerned about indicators. Usually do not halt FYCOMPA with out very first chatting using your healthcare supplier.

In a single placebo-controlled clinical demo, the effects of modafinil withdrawal were being monitored adhering to 9 months of modafinil use. There were no documented withdrawal signs and symptoms with modafinil for the duration of 14 times of observation, Though sleepiness returned in narcoleptic people.

Metabolism: Modafinil undergoes hepatic metabolism by way of several pathways, which includes CYP3A4. eighty% of your dose is recovered during the urine in the form of metabolites.

Stay clear of concomitant use of tucatinib with CYP3A substrates, the place negligible concentration alterations may perhaps result in severe or daily life-threatening toxicities. If unavoidable, cut down CYP3A substrate dose according to item labeling.

steroid hormones, for example estradiol, progesterone or cortisol. Modafinil could have an adverse effect on hormonal contraceptives (like birth Command pills, patches, etc.) for as much as per month just after discontinuation.[133] Each modafinil and armodafinil in the United States and the United Kingdom include package inserts that highlight the interaction amongst these remedies and hormonal delivery control.[86] Modafinil may perhaps induce cytochrome P450 enzymes that are involved in the clearance of steroid hormones taken as hormonal contraceptives, decreasing their efficiency, which may bring about pregnancy check here Even with getting the start Regulate medication.

modafinil will enhance the amount or outcome of diazepam intranasal by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Powerful or average CYP2C19 inhibitors may perhaps minimize fee of diazepam elimination, therefore growing adverse reactions to diazepam.

dizziness; sleepiness; tiredness; irritability; falls; nausea and vomiting; fat gain; vertigo (feeling of spinning); problems walking Ordinarily; problems with muscle mass coordination; headache; bruising; abdominal pain; panic FYCOMPA is a controlled material (CIII) because it may be abused or bring on drug dependence.

Often talk to your Health care service provider to make sure the knowledge exhibited on this web page applies to your individual circumstances.

The equivalent armodafinil dose to this is a hundred and fifty mg, which happens to be the dosage equipped in the generic variations Artvigil and Modvigil.

The exact same can happen with modafinil— Which explains why it’s most effective to ensure there are no troubles right before jumping straight into a sizable 400 mg dosage.